Biospec 7T MRI

Spectrometer Information

• 7T Bruker Biospec imaging located in Med. Sci D, Room 18D
• Horizontal Bore Imaging
• Uses Paravision 4 software on a RedHat Linux Workstation
• Standard Gradient set with max gradient of 95 mT/m
• Microgradient set with max gradient of 953 mT/m

Various Resonators

• 72 mm ID Rat whole Body Volume Coil
• 35 mm Mouse whole body Volume Coil
• 25 mm Mouse Brain Volume Coil
• 40 mm double tuned (HX) Rat Brain Volume Coil. X = ³¹P or ²³Na
• 20 mm dia. ¹H surface coil.

Animal Studies

Users generally provide anesthesia and any surgery on their own animals. However animal anesthesia and surgery services studies can be contracted through the Vet Med Microsurgery Core. Their rates for animal handling/surgery are in addition to the the spectrometer use rates. Please ciontact Dr. Yi-Je (Jay) Chen at [email protected] for more information.

Examples of Spectrometer Use

• Bumetanide Inhibition of the Blood-Brain Barrier Na-K-Cl Cotransporter Reduces Edema Formation in the Rat Middle Cerebral Artery Occlusion Model of Stroke http://www.nature.com/jcbfm/journal/v24/n9/abs/9591609a.html
• Cerebral Blood Flow and Cerebral Edema in Rats With Diabetic Ketoacidosis http://diabetes.diabetesjournals.org/content/57/10/2588.short
• Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood–brain barrier Na/H exchanger. http://www.nature.com/jcbfm/journal/v33/n2/abs/jcbfm2012160a.html
• Mixing of concentrated oil-in-water emulsions measured by nuclear magnetic resonance imaging
•  http://scitation.aip.org/content/aip/journal/pof2/15/9/10.1063/1.1583731
• Observation of the transition state for pressure-induced BO₃→ BO₄conversion in glass. http://www.sciencemag.org/content/345/6200/1027.short
• Studies of the interactions of an MRI system with the shielding in a combined PET/MRI scanner. http://iopscience.iop.org/0031-9155/55/1/016