The NMR Facility provides qualified researchers in the biological, medical,
and physical sciences access to state-of-the-art NMR instrumentation for
spectroscopy and imaging. At present the Facility operates 10 spectrometers of varying purposes and capabilities, four of which are
housed in Building MS1-D and four, operated jointly with the Chemistry
Department, in the Chemistry building. Four instruments are largely devoted to
structural characterization of organic and inorganic molecules. Two vertical
bore spectrometers are used primarily for solution studies of biomolecules, with an additional
vertical bore instrument for in vitro biological studies. Two horizontal magnet bore spectrometers are utilized
for in vivo spectroscopy and imaging of small animals, imaging of materials,
and in vitro spectroscopy of perfused organs. One spectrometer is
devoted to solid state NMR spectroscopy. All of the spectrometers are multinuclear and a large variety of
liquids, solids, surface, and imaging coils are available for use. The Facility also
has Linux computers for off-line data processing. Listed below are the
NMR spectrometers with their field strengths and primary use.
|
Spectrometer |
Proton Frequency |
Tesla |
Primary Use |
Location |
|
Avance 600 |
600 MHz |
14.1 |
Liquids spectroscopy |
MS1-D |
|
VNMRS 600 |
600 MHz |
14.1 |
Liquids spectroscopy |
Chem 93 |
|
Avance 500 |
500 MHz |
11.75 |
Solids spectroscopy |
Kemper 51 |
|
Avance 500 |
500 MHz |
11.75 |
Liquids spectroscopy |
MS1-D |
|
Avance 400 |
400 MHz |
9.4 |
In vitro spectroscopy |
MS1-D |
|
Inova-400 |
400 MHz |
9.4 |
Liquids spectroscopy |
Chem 93 |
|
Mercury-300 |
300 MHz |
7.05 |
Liquids spectroscopy |
Chem 93 |
|
MercuryPlus-300 |
300 MHz |
7.05 |
Liquids spectroscopy |
Chem 3470 |
|
Biospec 7T |
300 MHz |
7.05 |
In vivo spectroscopy, imaging |
MS1-D |
|
Tecmag |
26 MHz |
0.6 |
Imaging |
FS&T |
The Facility provides an annual training class (offered every Fall quarter as BCM 230) to the campus to enable users with long term research projects to independently operate the spectrometers. For those needing occasional NMR data, the Facility has trained personnel to obtain spectra. Further information on the Facility including spectrometer scheduling procedures are available from the Facility office, 752-7677 or jsderopp@ucdavis.edu
Research at the Facility covers a wide range of fields. Some of the current projects follow. Organic and inorganic chemists characterize natural and synthesized molecules via NMR studies. In the biomedical field, in vivo spectroscopy and imaging are being used to study heart and brain metabolism, probe effects of drugs in shock therapy, and investigate oxygen binding to myoglobin in tissue. Biochemists and chemists are studying protein, nucleic acid, and carbohydrate structure/function relationships using liquids NMR. Chemical engineers utilize imaging methods to study multiphase transport phenomena, and food scientists are investigating hardening and ripening in foodstuffs such as vegetables and fruits by magnetic resonance imaging. Over sixty Campus faculty from more than two dozen departments utilize the Facility annually.